唯一通讯单位！上海交通大学李茜/王黎/窦红静团队，最新Nature Methods！

TL;DR - A Nature Methods study introduces kpiCells, programmable biomimetic artificial cells that independently tune membrane organization, internal mechanics, and ligands to study immunological synapses. The platform enables multiscale force measurements and may improve CAR-T activation and expansion.

• kpiCells reproduce physiologically relevant stiffness, viscoelasticity, deformability, and surface-ligand organization.
• Artificial antigen-presenting kpiCells recreate key stages of T-cell interaction, including contact, migration, stable adhesion, and detachment.
• DNA tension probes and AFM quantify piconewton-scale TCR forces and single-cell contact-force signatures.
• The platform demonstrates mechanically and chemically coordinated CAR-T stimulation with potential translational value.