Amplifying multiplex spatial profiling with tyramide oligonucleotides

TL;DR - PASTA is a method for integrating and amplifying protein and nucleic-acid signals in imaging-based spatial biology. It could make multiplex spatial profiling more flexible across assay types.

• Uses tyramide oligonucleotide conjugates for signal amplification.
• Supports both protein and nucleic-acid spatial measurements.
• Works with diverse assays that use horseradish peroxidase readout.
• Enables serial amplification and integration of multiple signals.