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Artefacts in single-cell mtDNA analyses misinform phylogenies

Nature Bioinformatics AI Caleb A. Lareau, Michael Spencer Chapman, Livius Penter, Tal Nawy, Dana Pe’er, Leif S. Ludwig 2026-08-19

TL;DR - This Nature publication reports that artefacts in single-cell mitochondrial DNA analyses can produce misleading phylogenies. Because only the title and citation are provided, the affected methods, artefact sources, and proposed remedies cannot be determined.

  • Focuses on phylogenetic inference from single-cell mitochondrial DNA data.
  • Warns that analytical artefacts may be mistaken for genuine evolutionary relationships.
  • Highlights the need to identify and control technical biases before interpreting mtDNA-derived lineage trees.

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