Sci Adv | 可介导原位免疫激活的CD5⁺树突状细胞机器人

TL;DR - Researchers developed magnetically guided CD5⁺ dendritic-cell microrobots that penetrate solid tumors and activate local immune cells rather than directly killing cancer cells. In a mouse colorectal cancer model, one injection plus magnetic navigation suppressed tumor growth and extended survival while aiming to limit systemic inflammation.

• The robots combine PD-L1-blocked CD5⁺ dendritic cells with internalized magnetic PLGA nanoparticles coated in tumor-cell membranes.
• Tumor-membrane antigens promote dendritic-cell maturation and antigen presentation through MHC-I/II, activating CD8⁺ T cells and polarizing macrophages toward the antitumor M1 state.
• Switchable magnetic fields form ribbon-like clusters for downstream vascular movement and chain-like clusters for upstream, vessel-wall-assisted movement.
• Magnetic targeting concentrates the robots near tumors, after which natural chemotaxis drives deeper extracellular-matrix penetration and localized immune activation.