Systems vaccinology and the architecture of human immunity

TL;DR - This Nature review surveys systems vaccinology and how integrated, data-driven analyses can characterize the architecture of human immune responses to vaccination. It highlights the challenge of translating research insights into clinical and regulatory practice.

• Reviews the current state of systems-level vaccine and immunity research.
• Focuses on understanding human immune responses through an integrated systems perspective.
• Examines barriers between research findings and practical clinical use.
• Discusses challenges in incorporating systems-vaccinology evidence into regulatory processes.