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Insights into longevity and virus-driven adaptation from Myotis bat genomes

Nature Bioinformatics AI Juan M. Vazquez, M. Elise Lauterbur, Saba Mottaghinia, Léa Gaucherand, Sarah Maesen, Michael Singer, Sarah Villa, Melanie Bucci, Devaughn Fraser, Genavieve Gray-Sandoval, Zeinab R. Haidar, Melissa Han, William Kohler, Tanya M. Lama, Amandine Le Corf, Clara Loyer, Dakota McMillan, Stacy Li, Johnathan Lo, Carine Rey, Samantha L. R. Capel, Kathleen Slocum, Melissa Sui, William Thomas, Janet Debelak Tyburec, Rachel Brem, Richard Miller, Michael Buchalski, Jose Pablo Vazquez-Medina, Sébastien Pfeffer, Lucie Etienne, David Enard, Peter H. Sudmant 2026-08-26

TL;DR - Comparative and functional analyses of Myotis bat genomes identify distinctive adaptations in virus-interacting proteins and longevity-associated pathways. The study connects bats’ responses to viral pressures with their unusually long lifespans.

Compares genomes across Myotis bats to characterize evolutionary adaptations.
Finds unique patterns of change in proteins that interact with viruses.
Identifies adaptations in biological pathways associated with longevity.
Links two prominent features of bat biology: viral adaptation and extended lifespan.

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