A binding-to-release strategy for targeted anticancer drug delivery

TL;DR - This Nature study introduces a binding-to-release drug conjugate strategy that releases anticancer payloads at targeted tumours without requiring cellular internalization. The approach could improve tumour specificity and efficacy while expanding the range of addressable therapeutic targets.

• Payload release is triggered by target binding rather than uptake into cells.
• Avoiding the internalization requirement broadens potential targets beyond those suitable for conventional drug conjugates.
• The strategy is reported to improve tumour-specific delivery and therapeutic efficacy.
• The provided summary does not include quantitative efficacy or safety results.