Aberrant excitatory neuronal ERBB4 promotes Alzheimer’s disease pathology

TL;DR - A Nature study links aberrant ERBB4 activity in excitatory neurons to Alzheimer’s disease pathology. The supplied abstract snippet suggests early synapse loss may occur without neuroinflammation alone being necessary.

• Focuses on neuronal ERBB4 as a potential driver of Alzheimer’s pathology.
• Challenges models that treat neuroinflammation as essential for early synapse loss.
• The provided content does not include experimental methods, effect sizes, or therapeutic findings.