Granule cells reorient cortical trajectories to separate contexts

TL;DR - Simultaneous imaging in mice learning two skills showed that premotor-cortex activity trajectories generalize across contexts, whereas cerebellar granule-cell trajectories coherently reorient to distinguish them. The findings suggest a neural mechanism that balances shared skill representations with context separation.

• Researchers simultaneously imaged premotor cortex and cerebellar granule cells during parallel skill learning.
• Cortical trajectories generalized between the two learned contexts.
• Granule-cell trajectories reoriented away from one another, producing context-specific separation.
• This complementary coding may enable generalization without conflating distinct contexts.