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SPIFFI enables single-shot super-resolution and multidimensional imaging

Nature Methods Computational Imaging Wei Guo, Lely Feletti, Aleksandra Radenovic 2026-08-31

TL;DR - SPIFFI is a polarimetric imaging method for single-shot, real-time super-resolution and multidimensional imaging of live-cell samples. It could help capture fine spatial and additional multidimensional information without relying on repeated acquisitions.

  • Uses a polarimetric approach to acquire imaging information.
  • Supports single-shot super-resolution imaging.
  • Enables real-time observation of live-cell samples.
  • Detailed performance metrics and experimental results are not provided in the supplied content.

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