Human stewardship in the age of organoids

TL;DR - This Nature Methods commentary argues that organoid research needs continuous, integrated human stewardship rather than one-time ethics reviews. Such oversight must evolve with the science to respect the human origins of organoid models.

• Organoids are becoming increasingly important models in biomedical research.
• Episodic ethics review may not adequately address issues arising throughout the research lifecycle.
• Stewardship should be sustained and adapt alongside scientific advances.
• Responsible governance should explicitly recognize that organoids originate from human biological materials.