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NucleicBERT interprets RNA sequence space through self-supervised language modelling

Nature Machine Intelligence Bioinformatics AI Utkarsh Upadhyay, Julian Herold, Markus Götz, Alexander Schug 2026-09-03

TL;DR - NucleicBERT is a self-supervised language model trained on large-scale RNA sequence data to learn biologically meaningful patterns without relying on extensive annotations. It could help researchers interpret RNA structure and function from abundant but sparsely annotated sequences.

  • Addresses the scarcity of RNA annotations by learning directly from sequence correlations.
  • Uses self-supervised language modelling across large-scale RNA data.
  • Extracts biologically meaningful patterns from RNA sequence space.
  • Aims to improve inference of RNA structure and function.

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