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MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography

Nature Methods Bioinformatics AI Lorenz Lamm, Simon Zufferey, Hanyi Zhang, Ricardo D. Righetto, Florent Waltz, Wojciech Wietrzynski, Kevin A. Yamauchi, Alister Burt, Ye Liu, Antonio Martinez-Sanchez, Sebastian Ziegler, Fabian Isensee, Julia A. Schnabel, Benjamin D. Engel, Tingying Peng 2026-09-08

TL;DR - MemBrain v2 is an end-to-end tool for analyzing membranes in cryo-electron tomography datasets. It streamlines membrane segmentation, membrane protein localization, and spatial analysis through user-friendly workflows.

  • Integrates multiple membrane-analysis tasks into a single workflow.
  • Supports segmentation of membranes in cryo-electron tomograms.
  • Provides tools for localizing membrane proteins and analyzing their spatial organization.
  • Is designed for use across diverse datasets.

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