Predicting genome-wide functional constraints with GPN-Star

TL;DR - GPN-Star is a genomic language model designed to predict genome-wide functional constraints and genetic variant effects across species. Its phylogeny-aware architecture processes whole-genome alignment data with an emphasis on scalability and flexibility.

• Uses evolutionary relationships encoded in whole-genome alignments.
• Supports cross-species genetic variant effect prediction.
• Targets scalable analysis of functional constraints across entire genomes.
• The provided abstract does not include quantitative performance results.