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A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals

Nature Methods Neurotechnology Zifang Zhao, Hongyu Chang, Praveen Paudel, Jaehyo Park, Can Liu, Maria Q. Aurelio, Azahara Oliva, Antonio Fernandez-Ruiz 2026-09-10

TL;DR - WILD is a wireless modular platform for recording neural activity and behavior while delivering closed-loop optogenetic stimulation in freely moving small animals. It enables brain studies in both laboratory and naturalistic environments.

  • Records neuronal activity, animal movement, and video of the environment or eye movements.
  • Integrates onboard data analysis with triggered optogenetic stimulation.
  • Supports closed-loop experiments without restricting animals through wired equipment.
  • Targets studies in freely moving small animals such as mice.

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