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Encoded and non-genetic protein variants expand human functional proteome

Nature Proteomics Vyacheslav Tretyachenko, Tehila Leiman, David Morgenstern, Yishai Levin, Omer Asraf, Orna Dahan, Dvir Dahary, Yitzhak Pilpel 2026-09-14

TL;DR - This Nature paper examines how genetically encoded and non-genetic protein variants broaden the human functional proteome. Only the title and publication metadata are provided, so specific methods and findings cannot be assessed.

  • Published online in Nature on 14 September 2026.
  • Focuses on protein-level diversity beyond canonical gene-encoded forms.
  • Suggests that both encoded variants and non-genetic modifications contribute to functional proteome expansion.
  • The provided content does not specify the variants studied, experimental approach, or quantitative results.

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