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Mitochondrial fission factor senses and governs ferroptosis

Nature Bioinformatics AI Songjun Dai, Xiaoyan Dai, Tingting Zhang, Yuanyuan Qi, Xinquan Yang, Pengfei Diao, Chaodong Ge, Wenxiang Huang, Jisheng Ran, Xueliang Yang, Peng Zhang, Keke Zheng, Ruijun Wang, Hong Qian, Kunxiao Zhang, Junbing Wu, Caiyun Fu, Qian Ba, Junxia Min, Fudi Wang, Qiang Zhang 2026-09-16

TL;DR - A Nature study identifies mitochondrial fission factor (MFF) as a selective promoter of ferroptosis and introduces MFF–SPARK, a sensor for studying and screening this cell-death pathway. The platform could accelerate discovery of ferroptosis-sensitizing compounds and upstream MFF regulators.

MFF is a mitochondrial–peroxisomal fission adaptor with a newly identified pro-ferroptotic role.
MFF–SPARK enables high-content screening of compounds that sensitize cells to ferroptosis.
The sensor can also help identify upstream biological regulators of MFF.

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