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The lipidomic architecture of the mouse brain

Nature Bioinformatics AI Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, Leila Haj Abdullah Alieh, Irmak Kaysudu, Francesca Venturi, Hannah Hochgerner, Alessandro Valente, Colas Droin, Daniel Trejo Banos, Irina Khven, Jean Andrea Maillat, Anne-Laure Mahul-Mellier, Antonino Asaro, Doğukan H. Ülgen, Pavel Barahtjan, Ece Z. Asirim, Anita Nasrallah, Carmen Sandi, Ekaterina Krymova, Giovanni D’Angelo, Gioele La Manno 2026-09-23

TL;DR - A spatial lipidomic atlas maps the mouse brain into more than 500 biochemical territories that align with cell types and neural connectivity. It reveals fine-grained regional organization and lipid remodeling during pregnancy.

The atlas identifies over 500 distinct biochemical territories across the mouse brain.
Lipidomic patterns mirror known cell-type distributions and connectivity.
The study captures oligodendrocyte heterogeneity and zonation within the ventricular system.
Pregnancy remodels aspects of the brain’s spatial lipidomic architecture.

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