Spatially resolved chromatin architectures in mammalian brain tissues

TL;DR - Spatial Hi-C maps chromatin organization while preserving tissue location, revealing regional and cell-type-specific differences in adult and developing mouse brains.

• Applies spatially resolved Hi-C to mammalian brain tissue.
• Identifies variation in chromatin architecture across brain regions and cell types.
• Covers both adult and developing mouse brains, enabling comparison across developmental stages.
• Demonstrates how spatial genomics can connect 3D genome organization with tissue context.