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Spatially resolved chromatin architectures in mammalian brain tissues

Research Spatial Genomics

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TL;DR - Spatial Hi-C maps chromatin organization while preserving tissue location, revealing regional and cell-type-specific differences in adult and developing mouse brains.

  • Applies spatially resolved Hi-C to mammalian brain tissue.
  • Identifies variation in chromatin architecture across brain regions and cell types.
  • Covers both adult and developing mouse brains, enabling comparison across developmental stages.
  • Demonstrates how spatial genomics can connect 3D genome organization with tissue context.

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Spatially resolved chromatin architectures in mammalian brain tissues

Nature Methods Zhenping Chen, Maoni Guo, Lin Zhang, Hao Yu, Xinxin Wang, Xinrui Yu, Mingyue Chen, Junjie Lv, Zhisong Chen, Changjun Peng, Qian Gong, Qiao Zhang, Ru Guo, Yiping Huang, Lei Gao, Shan Jiang, Junmei Wang, Zhihua Zhang, Jianliang Qian, Jianrong Wang, Jiang Liu, Xuepeng Chen 2026-09-25 doi:10.1038/s41592-026-03218-3
Public signals OpenAlex citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-26 14:14:01.933070 UTC

TL;DR - Spatial Hi-C maps chromatin organization while preserving tissue location, revealing regional and cell-type-specific differences in adult and developing mouse brains.

  • Applies spatially resolved Hi-C to mammalian brain tissue.
  • Identifies variation in chromatin architecture across brain regions and cell types.
  • Covers both adult and developing mouse brains, enabling comparison across developmental stages.
  • Demonstrates how spatial genomics can connect 3D genome organization with tissue context.
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