Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila

TL;DR - A Nature study identifies Lsp2 as a physiological link between dietary essential amino acids, mTORC1 signaling, and TOP mRNA translation in Drosophila. Loss of Lsp2 reduces TOP mRNA translation and extends lifespan, connecting nutrient-responsive translation to longevity.

• Dietary essential amino acids induce the Lsp2 protein.
• Lsp2 acts as a key downstream effector of mTORC1.
• Lsp2-deficient flies show reduced translation of TOP mRNAs.
• Loss of Lsp2 is associated with improved longevity.