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Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila

Research Aging Biology

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TL;DR - A Nature study identifies Lsp2 as a physiological link between dietary essential amino acids, mTORC1 signaling, and TOP mRNA translation in Drosophila. Loss of Lsp2 reduces TOP mRNA translation and extends lifespan, connecting nutrient-responsive translation to longevity.

  • Dietary essential amino acids induce the Lsp2 protein.
  • Lsp2 acts as a key downstream effector of mTORC1.
  • Lsp2-deficient flies show reduced translation of TOP mRNAs.
  • Loss of Lsp2 is associated with improved longevity.

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Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila

Nature Jun Wang, Zixin Cai, Jiaojiao Gu, Shiqi Xiong, Jianhan Yi, Meng Yang, Kexin Chang, Xinrui Ning, Yilin Wen, Yan Yan, Jiongming Lu, Yirong Wang, Zongzhao Zhai 2026-09-23 doi:10.1038/s41586-026-11029-x
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Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-26 14:04:46.226327 UTC

TL;DR - A Nature study identifies Lsp2 as a physiological link between dietary essential amino acids, mTORC1 signaling, and TOP mRNA translation in Drosophila. Loss of Lsp2 reduces TOP mRNA translation and extends lifespan, connecting nutrient-responsive translation to longevity.

  • Dietary essential amino acids induce the Lsp2 protein.
  • Lsp2 acts as a key downstream effector of mTORC1.
  • Lsp2-deficient flies show reduced translation of TOP mRNAs.
  • Loss of Lsp2 is associated with improved longevity.
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