TRAM promotes Toll-like-receptor-free myddosome signal transduction

TL;DR - A Nature study identifies TRAM as a regulator that enables durable myddosome signaling independently of Toll-like receptors. TRAM promotes myddosome maturation by releasing MyD88 from the TLR–TIRAP complex.

• TRAM regulates assembly of the myddosome, an innate immune signaling complex.
• It dissociates MyD88 from the TLR–TIRAP complex.
• This release enables myddosome maturation and sustained downstream signal transduction.