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TRAM promotes Toll-like-receptor-free myddosome signal transduction

Research Immunology

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TL;DR - A Nature study identifies TRAM as a regulator that enables durable myddosome signaling independently of Toll-like receptors. TRAM promotes myddosome maturation by releasing MyD88 from the TLR–TIRAP complex.

  • TRAM regulates assembly of the myddosome, an innate immune signaling complex.
  • It dissociates MyD88 from the TLR–TIRAP complex.
  • This release enables myddosome maturation and sustained downstream signal transduction.

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TRAM promotes Toll-like-receptor-free myddosome signal transduction

Nature Daniel Fisch, Vaani Ohri, Eleni Anastasakou, Lucia J. Wesemann, Joon H. Choi, Katherine E. Lindblad, Jonathan C. Kagan 2026-09-23 doi:10.1038/s41586-026-11052-y
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-26 14:04:44.868114 UTC

TL;DR - A Nature study identifies TRAM as a regulator that enables durable myddosome signaling independently of Toll-like receptors. TRAM promotes myddosome maturation by releasing MyD88 from the TLR–TIRAP complex.

  • TRAM regulates assembly of the myddosome, an innate immune signaling complex.
  • It dissociates MyD88 from the TLR–TIRAP complex.
  • This release enables myddosome maturation and sustained downstream signal transduction.
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