南京大学「国家优青」朱少林最新Nature子刊丨配体接力催化构建手性N-螺杂环！

TL;DR - A Nature Communications study introduces ligand-relay cobalt catalysis for directly converting stable N-heteroarenes into chiral N-spirocycles. Separating metal migration from stereocontrol overcomes competing catalytic requirements.

• An achiral phosphine promotes remote 1,4-Co/H migration, while a chiral PHOX ligand controls dearomative [3+2] spiroannulation.
• Quinoline and alkyne substrates achieve high yields and enantioselectivity; the method also supports pyridines, intramolecular reactions, and downstream derivatization.
• Isotope labeling, stoichiometric cobalt complexes, control experiments, spectroscopy, and calculations support ligand exchange after migration rather than a simple Co(0) pathway.