南京大学「国家优青」朱少林最新Nature子刊丨配体接力催化构建手性N-螺杂环！

TL;DR - A Nature Communications study introduces ligand-relay cobalt catalysis for directly converting stable N-heteroarenes into chiral N-spirocycles. Separating metal migration from stereocontrol overcomes competing catalytic requirements.

• An achiral phosphine promotes remote 1,4-Co/H migration, while a chiral PHOX ligand controls dearomative [3+2] spiroannulation.
• Quinoline and alkyne substrates achieve high yields and enantioselectivity; the method also supports pyridines, intramolecular reactions, and downstream derivatization.
• Isotope labeling, stoichiometric cobalt complexes, control experiments, spectroscopy, and calculations support ligand exchange after migration rather than a simple Co(0) pathway.

TL;DR - A Nature Communications paper reports palladium-catalyzed dynamic kinetic asymmetric dearomatization of unactivated racemic biaryls. Alkyne migratory insertion enables stereoconvergent synthesis of complex, three-dimensional chiral fused rings.

• Dynamic axial rotation and selective palladium catalysis convert racemic biaryls into a favored enantiomer.
• 2-Alkynyl phenols or anilines bridge reaction fragments and trap intermediates through oxygen- or nitrogen-based cyclization.
• Kinetic studies, controls, DFT, IGMH, and distortion–interaction analyses probe the catalytic mechanism and stereoselectivity.
• Hydrogenation and functional-group transformations demonstrate the products’ utility as editable chiral building blocks.

TL;DR - A Nature Cell Biology study identifies “budding-type fission,” a previously unknown process that regenerates functional lysosomes from damaged ones during hypoxia-reoxygenation stress.

• Mitochondria-derived vesicles deliver the fission adaptor MFF to damaged lysosomes.
• MFF recruits DRP1, driving membrane budding and scission into small, functional lysosomes independently of autophagic lysosome reformation.
• The ITM2C–MIRO2–MFF–DRP1 axis coordinates vesicle formation, lysosome targeting, and fission.
• AMPK activation promotes this pathway, suggesting relevance to lysosome quality control during ischemia-reperfusion stress.

TL;DR - A Nature Microbiology study reports that all-trans retinoic acid (ATRA), a vitamin A metabolite, suppresses systemic inflammation caused by SFTSV in mice, suggesting a potential therapeutic target for the often-fatal tick-borne infection.

• SFTSV patients showed depleted vitamin A and ATRA levels, correlating with more severe systemic inflammation and higher mortality risk.
• In mice, intraperitoneal ATRA reduced virus-induced hyperinflammation through PPARγ.
• ATRA promoted RXRα–PPARγ complex formation, sequestering JUN and reducing AP-1-driven inflammatory genes such as IL-6.
• The findings identify retinoid signaling as an immunometabolic checkpoint and potential target for controlling cytokine storms.

TL;DR - A Nature study identifies isopropyl myristate (IPM) as a queen-produced odor that suppresses reproduction in female naked mole-rats. The finding reveals a mammalian chemical mechanism analogous to pheromone-based reproductive control in eusocial insects.

• Queens produce high IPM levels, particularly during ovulation, while other adults produce almost none.
• Olfactory, electrophysiological, and brain-imaging experiments confirmed that naked mole-rats detect and neurologically respond to IPM.
• IPM exposure raises prolactin in non-breeding females, suppressing their reproductive function.
• Applying IPM prevented pregnancy and maintained colony stability after queen removal; stopping treatment triggered conflict and the emergence of a new queen.