湖南师范大学黄学良&中国科学院大学汪志祥最新Nature子刊丨炔迁移插入驱动联芳基动态去芳构化！

TL;DR - A Nature Communications paper reports palladium-catalyzed dynamic kinetic asymmetric dearomatization of unactivated racemic biaryls. Alkyne migratory insertion enables stereoconvergent synthesis of complex, three-dimensional chiral fused rings.

• Dynamic axial rotation and selective palladium catalysis convert racemic biaryls into a favored enantiomer.
• 2-Alkynyl phenols or anilines bridge reaction fragments and trap intermediates through oxygen- or nitrogen-based cyclization.
• Kinetic studies, controls, DFT, IGMH, and distortion–interaction analyses probe the catalytic mechanism and stereoselectivity.
• Hydrogenation and functional-group transformations demonstrate the products’ utility as editable chiral building blocks.