Nature子刊：华科宋质银团队发现新型溶酶体更新方式——出芽型分裂，由线粒体来源囊泡驱动

TL;DR - A Nature Cell Biology study identifies “budding-type fission,” a previously unknown process that regenerates functional lysosomes from damaged ones during hypoxia-reoxygenation stress.

• Mitochondria-derived vesicles deliver the fission adaptor MFF to damaged lysosomes.
• MFF recruits DRP1, driving membrane budding and scission into small, functional lysosomes independently of autophagic lysosome reformation.
• The ITM2C–MIRO2–MFF–DRP1 axis coordinates vesicle formation, lysosome targeting, and fission.
• AMPK activation promotes this pathway, suggesting relevance to lysosome quality control during ischemia-reperfusion stress.