Nature子刊：朱书/刘玮/黎浩发现，这种维生素A代谢物可抑制致命蜱传病毒引起的系统性炎症

TL;DR - A Nature Microbiology study reports that all-trans retinoic acid (ATRA), a vitamin A metabolite, suppresses systemic inflammation caused by SFTSV in mice, suggesting a potential therapeutic target for the often-fatal tick-borne infection.

• SFTSV patients showed depleted vitamin A and ATRA levels, correlating with more severe systemic inflammation and higher mortality risk.
• In mice, intraperitoneal ATRA reduced virus-induced hyperinflammation through PPARγ.
• ATRA promoted RXRα–PPARγ complex formation, sequestering JUN and reducing AP-1-driven inflammatory genes such as IL-6.
• The findings identify retinoid signaling as an immunometabolic checkpoint and potential target for controlling cytokine storms.