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Nature:堪比《甄嬛传》,裸鼹鼠“女王”通过“下药”,让其他雌性绝育

WeChat: 生物世界 Animal Social Biology 2026-07-20

TL;DR - A Nature study identifies isopropyl myristate (IPM) as a queen-produced odor that suppresses reproduction in female naked mole-rats. The finding reveals a mammalian chemical mechanism analogous to pheromone-based reproductive control in eusocial insects.

  • Queens produce high IPM levels, particularly during ovulation, while other adults produce almost none.
  • Olfactory, electrophysiological, and brain-imaging experiments confirmed that naked mole-rats detect and neurologically respond to IPM.
  • IPM exposure raises prolactin in non-breeding females, suppressing their reproductive function.
  • Applying IPM prevented pregnancy and maintained colony stability after queen removal; stopping treatment triggered conflict and the emergence of a new queen.

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