Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo

TL;DR - LATeNT is a light-activated tetanus neurotoxin enabling precise, reversible control over cellular exocytosis. It offers a targeted way to inhibit synaptic transmission and other secretion processes in vivo.

• Provides spatial and temporal control of proteolysis and exocytosis inhibition.
• Suppresses neuronal synaptic transmission in vivo when activated by light.
• Abolishes endogenous insulin secretion in pancreatic beta cells in a light-dependent manner.
• Extends optogenetic control beyond neurons to secretion in other cell types.