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Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo

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TL;DR - LATeNT is a light-activated tetanus neurotoxin enabling precise, reversible control over cellular exocytosis. It offers a targeted way to inhibit synaptic transmission and other secretion processes in vivo.

  • Provides spatial and temporal control of proteolysis and exocytosis inhibition.
  • Suppresses neuronal synaptic transmission in vivo when activated by light.
  • Abolishes endogenous insulin secretion in pancreatic beta cells in a light-dependent manner.
  • Extends optogenetic control beyond neurons to secretion in other cell types.

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Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo

Nature Methods Heegwang Roh, Dongwook Kim, Byeongchan Kim, Younghyeon Jeon, Shreya Malhotra, Hyeonho Kim, Yeonghye Kim, Martin Jacko, Peter M. Klein, Chang Lin, Fei Xu, Ivan Soltesz, Ji Won Um, Alice Y. Ting 2026-07-30 doi:10.1038/s41592-026-03176-w
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-08-28 14:33:41.107549 UTC

TL;DR - LATeNT is a light-activated tetanus neurotoxin enabling precise, reversible control over cellular exocytosis. It offers a targeted way to inhibit synaptic transmission and other secretion processes in vivo.

  • Provides spatial and temporal control of proteolysis and exocytosis inhibition.
  • Suppresses neuronal synaptic transmission in vivo when activated by light.
  • Abolishes endogenous insulin secretion in pancreatic beta cells in a light-dependent manner.
  • Extends optogenetic control beyond neurons to secretion in other cell types.
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