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Sequential reading of a stepwise-shortened peptide immobilized on nanopore

Research Protein Sequencing

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TL;DR - A nanopore-based “chop and measure” method sequences immobilized peptides at single-amino-acid resolution, potentially advancing precise protein analysis.

Enzymatic digestion removes one N-terminal residue at a time.
Nanopore measurements read each progressively shortened peptide.
Repetitive N-terminus re-reading supports sequential residue identification.

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Sequential reading of a stepwise-shortened peptide immobilized on nanopore

Nature Jialu Chen, Hanhan Zhang, Kefan Wang, Tian Li, Wen Sun, Zixuan Wang, Xinmeng Gao, Zhenyuan Cao, Yusheng Ouyang, Lang Yao, Yifan Wang, Yunqi Xiao, Ruidong Li, Xingwang An, Xinyi Dai, Lulu Zhao, Lu Qian, Panke Zhang, Shuo Huang 2026-07-29 doi:10.1038/s41586-026-10881-1

Public signals OpenAlex citations 0 · Semantic Scholar citations 0 · Semantic Scholar influential citations 0

Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-08-28 14:32:57.580588 UTC

TL;DR - A nanopore-based “chop and measure” method sequences immobilized peptides at single-amino-acid resolution, potentially advancing precise protein analysis.

Enzymatic digestion removes one N-terminal residue at a time.
Nanopore measurements read each progressively shortened peptide.
Repetitive N-terminus re-reading supports sequential residue identification.

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