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In situ structure of the poxvirus portal complex

Research Structural Biology

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TL;DR - Cryo-electron tomography reveals the in situ structure of a conserved hexameric portal complex spanning the vaccinia virus core wall. The structure connects this complex to viral assembly, mRNA release, and genome uncoating.

  • The portal complex consists of six subunits.
  • It spans the core wall of vaccinia virus.
  • Its architecture is conserved among poxviruses.
  • The findings provide structural context for several essential stages of the viral life cycle.

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In situ structure of the poxvirus portal complex

Nature Thomas Calcraft, Miguel Hernandez-Gonzalez, Michael Way, Peter B. Rosenthal 2026-07-29 doi:10.1038/s41586-026-10856-2
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-08-28 14:32:42.336398 UTC

TL;DR - Cryo-electron tomography reveals the in situ structure of a conserved hexameric portal complex spanning the vaccinia virus core wall. The structure connects this complex to viral assembly, mRNA release, and genome uncoating.

  • The portal complex consists of six subunits.
  • It spans the core wall of vaccinia virus.
  • Its architecture is conserved among poxviruses.
  • The findings provide structural context for several essential stages of the viral life cycle.
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