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ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Research Cancer Cell Plasticity

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TL;DR - A Nature paper reporting that the RNA-binding protein ZFP36L2 drives stress-adaptive cellular plasticity in intestinal regeneration and colorectal cancer metastasis; only the abstract teaser is available, so details are limited. Note: this is wet-lab cancer/regeneration biology with no stated AI or computational-method component.

  • Identifies ZFP36L2, an RNA-binding protein of the ZFP36 family (post-transcriptional regulators that bind AU-rich elements in mRNA), as the orchestrator of a stress-adaptive plasticity program.
  • Links the same regulatory axis across two contexts: physiological intestinal regeneration and pathological colorectal cancer metastasis, implying shared reactivation of a regenerative/fetal-like state in tumours.
  • Positions post-transcriptional (mRNA stability) control, rather than transcription-factor rewiring alone, as a lever on cell-state switching under stress.
  • Content provided is a single-sentence abstract line; no experimental models, effect sizes, datasets, or mechanistic targets are given, so specific results cannot be reported here.

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ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Nature Qingwen Jiang, Manisha S. Raghavan, Aileen M. Rodriguez, Morgan Lallo, Cyrus L. Tam, Saskia Hartner, Britney Forsyth, Ahmed Mahmoud, Fabian Zincke, Huiyong Zhao, Andrew Moorman, Sasha Balkaran, Kathleen Luckett, Jura Pintar, Yevgeniy Romin, Eric Chan, Anthony Santella, Bernadette Mödl, Farheen Shah, Ilyes Baali, Michael G. Kharas, Elisa de Stanchina, Nil Urganci, Jinru Shia, Dana Pe’er, Francisco Sanchez-Vega, Richard Koche, Quaid Morris, Joseph M. Chan, Karuna Ganesh 2026-08-05 doi:10.1038/s41586-026-10890-0
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-03 14:31:32.996517 UTC

TL;DR - A Nature paper reporting that the RNA-binding protein ZFP36L2 drives stress-adaptive cellular plasticity in intestinal regeneration and colorectal cancer metastasis; only the abstract teaser is available, so details are limited. Note: this is wet-lab cancer/regeneration biology with no stated AI or computational-method component.

  • Identifies ZFP36L2, an RNA-binding protein of the ZFP36 family (post-transcriptional regulators that bind AU-rich elements in mRNA), as the orchestrator of a stress-adaptive plasticity program.
  • Links the same regulatory axis across two contexts: physiological intestinal regeneration and pathological colorectal cancer metastasis, implying shared reactivation of a regenerative/fetal-like state in tumours.
  • Positions post-transcriptional (mRNA stability) control, rather than transcription-factor rewiring alone, as a lever on cell-state switching under stress.
  • Content provided is a single-sentence abstract line; no experimental models, effect sizes, datasets, or mechanistic targets are given, so specific results cannot be reported here.
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