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Shared principles of human and bacterial antiviral immunity

Research Antiviral Immunity

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TL;DR - This Nature Review identifies ancient, conserved principles shared by human antiviral immunity and bacterial anti-phage defenses. These parallels reveal common rules governing host–virus interactions across life.

  • Compares antiviral mechanisms in humans with bacterial defenses against phages.
  • Organizes shared mechanisms around pathogen sensing, signalling, and effector functions.
  • Argues that core antiviral strategies are evolutionarily ancient and conserved.
  • Provides a cross-domain framework for understanding immune defense.

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Shared principles of human and bacterial antiviral immunity

Nature Philip J. Kranzusch 2026-08-12 doi:10.1038/s41586-026-10756-5
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:27:54.931303 UTC

TL;DR - This Nature Review identifies ancient, conserved principles shared by human antiviral immunity and bacterial anti-phage defenses. These parallels reveal common rules governing host–virus interactions across life.

  • Compares antiviral mechanisms in humans with bacterial defenses against phages.
  • Organizes shared mechanisms around pathogen sensing, signalling, and effector functions.
  • Argues that core antiviral strategies are evolutionarily ancient and conserved.
  • Provides a cross-domain framework for understanding immune defense.
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