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Structural mechanism governing the directionality of bridge recombination

Research Genome Editing

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TL;DR - Cryo-EM structures reveal how IS621 bridge recombinase controls DNA excision and why it naturally favors insertion. The findings could guide the engineering of programmable bridge-editing tools.

  • Resolves structural mechanisms governing bridge recombination directionality.
  • Shows how IS621 bridge recombinase mediates DNA excision.
  • Explains the system’s natural preference for DNA insertion.
  • Provides a structural basis for designing programmable genome-editing technologies.

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Structural mechanism governing the directionality of bridge recombination

Nature Masahiro Hiraizumi, Januka S. Athukoralage, Nicholas T. Perry, Eisuke Tsujimoto, Nami Shiojiri, Naoto Nagahata, Lauren Lee, Gwanggyu Sun, Matthew G. Durrant, Sita S. Chandrasekaran, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu 2026-08-12 doi:10.1038/s41586-026-10903-y
Public signals OpenAlex citations 1
Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:27:51.799673 UTC

TL;DR - Cryo-EM structures reveal how IS621 bridge recombinase controls DNA excision and why it naturally favors insertion. The findings could guide the engineering of programmable bridge-editing tools.

  • Resolves structural mechanisms governing bridge recombination directionality.
  • Shows how IS621 bridge recombinase mediates DNA excision.
  • Explains the system’s natural preference for DNA insertion.
  • Provides a structural basis for designing programmable genome-editing technologies.
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