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Voltage imaging of neurons distributed across entire brains of larval zebrafish

Research Neuroscience Imaging

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TL;DR - Researchers achieved voltage imaging across much of the larval zebrafish brain at 200.8 Hz by optimizing a remote-scanning light-sheet microscope. This enables high-speed observation of neuronal electrical activity distributed across the brain.

  • Uses voltage imaging to monitor distributed neuronal activity.
  • Covers much of the larval zebrafish brain.
  • Achieves an imaging rate of 200.8 Hz.
  • Relies on an optimized remote-scanning light-sheet microscope.

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Voltage imaging of neurons distributed across entire brains of larval zebrafish

Nature Methods Zeguan Wang, Jie Zhang, Panagiotis Symvoulidis, Wei Guo, Davy Deng, Adam Amsterdam, Lige Zhang, Takato Honda, Steven Roche, Matthew A. Wilson, Edward S. Boyden 2026-08-14 doi:10.1038/s41592-026-03179-7
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:26:57.091942 UTC

TL;DR - Researchers achieved voltage imaging across much of the larval zebrafish brain at 200.8 Hz by optimizing a remote-scanning light-sheet microscope. This enables high-speed observation of neuronal electrical activity distributed across the brain.

  • Uses voltage imaging to monitor distributed neuronal activity.
  • Covers much of the larval zebrafish brain.
  • Achieves an imaging rate of 200.8 Hz.
  • Relies on an optimized remote-scanning light-sheet microscope.
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