🛰️ Daily AI Frontier
‹ back to 2026-08-20

Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit

Research Computational Chemistry

Ranking

Overall 69
Content 80
Popularity 44

Observed public metrics from 1 member.

Merged summary

TL;DR - Researchers developed a one-pot skeletal-editing reaction that converts isoxazoles into otherwise challenging pyrroles by replacing a ring oxygen atom with carbon. A computational model helps predict the reaction’s outcomes.

  • The transformation performs an oxygen-to-carbon skeletal edit rather than rebuilding the heterocycle from scratch.
  • The reaction proceeds through an N-propargylic enaminone intermediate.
  • The one-pot method provides access to pyrroles that are difficult to synthesize using existing approaches.
  • Computational prediction complements the reaction design by forecasting outcomes.

Sources (1)

Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit

Nature Abigail J. Bracken, Alexandra P. Lawrie, Isabella F. Romita, Mark D. Levin 2026-08-19 doi:10.1038/s41586-026-10933-6
Public signals OpenAlex citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-19 14:26:03.742310 UTC

TL;DR - Researchers developed a one-pot skeletal-editing reaction that converts isoxazoles into otherwise challenging pyrroles by replacing a ring oxygen atom with carbon. A computational model helps predict the reaction’s outcomes.

  • The transformation performs an oxygen-to-carbon skeletal edit rather than rebuilding the heterocycle from scratch.
  • The reaction proceeds through an N-propargylic enaminone intermediate.
  • The one-pot method provides access to pyrroles that are difficult to synthesize using existing approaches.
  • Computational prediction complements the reaction design by forecasting outcomes.
item →