Pervasive phosphorylation by phage T7 kinase disarms bacterial defences
Ranking
Overall
68
Content
80
Popularity
40
Observed public metrics from 1 member.
Merged summary
TL;DR - A Nature study reports that bacteriophage T7 uses its kinase, T7K, to phosphorylate nearly all bacterial-host and phage proteins during infection. This pervasive modification disables bacterial defence systems, revealing a broad phage strategy for overcoming host immunity.
- T7K drives extensive phosphorylation across both host and viral proteomes.
- The phosphorylation occurs during T7 infection and deactivates bacterial defence mechanisms.
- The findings identify proteome-wide kinase activity as a mechanism of phage immune evasion.
Sources (1)
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences
Public signals
OpenAlex citations 0 · Semantic Scholar citations 0 · Semantic Scholar influential citations 0
TL;DR - A Nature study reports that bacteriophage T7 uses its kinase, T7K, to phosphorylate nearly all bacterial-host and phage proteins during infection. This pervasive modification disables bacterial defence systems, revealing a broad phage strategy for overcoming host immunity.
- T7K drives extensive phosphorylation across both host and viral proteomes.
- The phosphorylation occurs during T7 infection and deactivates bacterial defence mechanisms.
- The findings identify proteome-wide kinase activity as a mechanism of phage immune evasion.