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Wake-activated neuronal populations that regulate sleep drive

Research Sleep Neuroscience

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TL;DR - A mouse study identifies wake-activated neuronal populations that are crucial for regulating sleep drive. Manipulating these cells can persistently reduce daily sleep, offering insight into the neural mechanisms that control sleep need.

  • Researchers combined whole-brain activity mapping, targeted cell manipulation, and electrophysiology.
  • The identified neuronal populations become active during wakefulness and contribute to sleep drive.
  • Targeting these cells produced sustained reductions in mice’s daily sleep amount.
  • The findings connect specific neural populations to the accumulation and regulation of sleep need.

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Wake-activated neuronal populations that regulate sleep drive

Nature William Joo, Clare Diester, Vassilis Bitsikas, Myrto Panopoulou, Amelia Hidalgo, Konstantinos Ntemos, Rodrigo C. G. Pena, Fabia Imhof, Iris Odstrcil, Flavio Donato, Geoffrey Fucile, Daniel Kroeger, Thomas E. Scammell, Alexander F. Schier 2026-08-19 doi:10.1038/s41586-026-10928-3
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-19 14:25:53.577051 UTC

TL;DR - A mouse study identifies wake-activated neuronal populations that are crucial for regulating sleep drive. Manipulating these cells can persistently reduce daily sleep, offering insight into the neural mechanisms that control sleep need.

  • Researchers combined whole-brain activity mapping, targeted cell manipulation, and electrophysiology.
  • The identified neuronal populations become active during wakefulness and contribute to sleep drive.
  • Targeting these cells produced sustained reductions in mice’s daily sleep amount.
  • The findings connect specific neural populations to the accumulation and regulation of sleep need.
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