Cell Stem Cell | 刘昭飞团队构建SMART平台：将肿瘤硬度转化为可识别的放射性药物靶点
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TL;DR - Researchers developed SMART, an engineered mesenchymal stem-cell platform that senses abnormal tissue stiffness and locally creates synthetic targets for existing radiopharmaceuticals. The approach could extend PET imaging and targeted radionuclide therapy to solid tumors—and potentially fibrotic diseases—that lack suitable natural molecular targets.
- SMART uses YAP/TAZ-mediated mechanosensing to trigger local expression of targets such as PSMA or SSTR2 in stiff diseased tissue.
- Engineered MSCs enabled PSMA-targeted PET imaging across PSMA-negative breast, colorectal, lung, and pancreatic tumor models, including metastatic lesions.
- After synthetic PSMA target formation, the albumin-binding radiopharmaceutical ^177Lu-AB-PSMA-617 accumulated in tumors and suppressed tumor growth in treatment experiments.
- The platform also visualized lung fibrosis and worked with iPSC-derived MSCs, suggesting potential beyond cancer and toward standardized cell production.
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Cell Stem Cell | 刘昭飞团队构建SMART平台：将肿瘤硬度转化为可识别的放射性药物靶点
TL;DR - Researchers developed SMART, an engineered mesenchymal stem-cell platform that senses abnormal tissue stiffness and locally creates synthetic targets for existing radiopharmaceuticals. The approach could extend PET imaging and targeted radionuclide therapy to solid tumors—and potentially fibrotic diseases—that lack suitable natural molecular targets.
- SMART uses YAP/TAZ-mediated mechanosensing to trigger local expression of targets such as PSMA or SSTR2 in stiff diseased tissue.
- Engineered MSCs enabled PSMA-targeted PET imaging across PSMA-negative breast, colorectal, lung, and pancreatic tumor models, including metastatic lesions.
- After synthetic PSMA target formation, the albumin-binding radiopharmaceutical ^177Lu-AB-PSMA-617 accumulated in tumors and suppressed tumor growth in treatment experiments.
- The platform also visualized lung fibrosis and worked with iPSC-derived MSCs, suggesting potential beyond cancer and toward standardized cell production.