Nature Cancer：王雄军团队等发现肿瘤内Treg细胞诱导NK细胞衰老，加速癌症进展
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TL;DR - A Nature Cancer study identifies a lactate–α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells (Ti-Tregs) that induces natural killer (NK) cell senescence and accelerates tumor progression. Targeting this pathway could strengthen antitumor immunity and improve adoptive NK-cell therapy.
- Ti-Tregs upregulate glutamate dehydrogenase 1 (GDH1), increasing α-ketoglutarate production in the lactate-rich tumor microenvironment.
- GDH1 lactylation promotes α-ketoglutarate generation, which drives ALKBH5-mediated Wnt2 expression.
- Increased WNT2 signaling induces NK-cell senescence, weakening immune surveillance and promoting tumor growth.
- Inhibiting GDH1 or deleting the lactate transporter SLC16A1 in Ti-Tregs reduced NK-cell senescence and improved adoptive NK-cell therapy in the reported models.
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Nature Cancer：王雄军团队等发现肿瘤内Treg细胞诱导NK细胞衰老，加速癌症进展
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TL;DR - A Nature Cancer study identifies a lactate–α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells (Ti-Tregs) that induces natural killer (NK) cell senescence and accelerates tumor progression. Targeting this pathway could strengthen antitumor immunity and improve adoptive NK-cell therapy.
- Ti-Tregs upregulate glutamate dehydrogenase 1 (GDH1), increasing α-ketoglutarate production in the lactate-rich tumor microenvironment.
- GDH1 lactylation promotes α-ketoglutarate generation, which drives ALKBH5-mediated Wnt2 expression.
- Increased WNT2 signaling induces NK-cell senescence, weakening immune surveillance and promoting tumor growth.
- Inhibiting GDH1 or deleting the lactate transporter SLC16A1 in Ti-Tregs reduced NK-cell senescence and improved adoptive NK-cell therapy in the reported models.