Nat Cell Biol | 宋彦龄团队解析肿瘤囊泡分泌昼夜节律，赋能时辰治疗新策略
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TL;DR - A Nature Cell Biology study introduces ctEV-CLOCK, a method for time-resolved isolation of circulating tumor-derived extracellular vesicles, and shows that their secretion and tumor-promoting activity follow circadian rhythms. Synchronizing targeted therapies with peak vesicle-protein abundance substantially improved efficacy in mouse tumor models.
- ctEV-CLOCK combines metabolic glycan labeling with tumor-marker-targeted aptamer click chemistry to isolate newly secreted ctEVs at 12-hour resolution.
- Across several mouse tumor models, ctEV abundance and pro-migratory, pro-invasive activity peaked during the nocturnal active phase; host-clock disruption largely abolished this rhythm.
- Nighttime ctEVs were enriched in actionable proteins, including HPSE and CD47, linking vesicle rhythms to angiogenesis, invasion, and immune evasion.
- Administering an HPSE inhibitor or anti-CD47 antibody near the corresponding ctEV protein peaks improved antitumor responses; suppressing extracellular-vesicle release eliminated the time-of-day advantage.
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Nat Cell Biol | 宋彦龄团队解析肿瘤囊泡分泌昼夜节律，赋能时辰治疗新策略
TL;DR - A Nature Cell Biology study introduces ctEV-CLOCK, a method for time-resolved isolation of circulating tumor-derived extracellular vesicles, and shows that their secretion and tumor-promoting activity follow circadian rhythms. Synchronizing targeted therapies with peak vesicle-protein abundance substantially improved efficacy in mouse tumor models.
- ctEV-CLOCK combines metabolic glycan labeling with tumor-marker-targeted aptamer click chemistry to isolate newly secreted ctEVs at 12-hour resolution.
- Across several mouse tumor models, ctEV abundance and pro-migratory, pro-invasive activity peaked during the nocturnal active phase; host-clock disruption largely abolished this rhythm.
- Nighttime ctEVs were enriched in actionable proteins, including HPSE and CD47, linking vesicle rhythms to angiogenesis, invasion, and immune evasion.
- Administering an HPSE inhibitor or anti-CD47 antibody near the corresponding ctEV protein peaks improved antitumor responses; suppressing extracellular-vesicle release eliminated the time-of-day advantage.