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Endocannabinoids facilitate reward engagement through retrograde gain control

Research Computational Neuroscience

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TL;DR - This Nature study identifies dynamic endocannabinoid release as a retrograde gain-control mechanism in a thalamostriatal circuit that promotes engagement during reward seeking. It clarifies how neuromodulatory signaling helps translate reward motivation into behavior.

Endocannabinoids act as retrograde signals within a thalamostriatal circuit.
Their dynamic release regulates circuit gain during reward-seeking behavior.
This mechanism facilitates behavioral engagement with potential rewards.
The findings connect circuit-level neuromodulation to motivated behavior.

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Endocannabinoids facilitate reward engagement through retrograde gain control

Nature David J. Marcus, Anthony E. English, Gunn Chun, Emmaline F. Seth, Rachel Oommen, Sabrina Hwang, Bailey A. Wells, Sean C. Piantadosi, Azra Suko, Sayaka J. Kenmochi, Anupritaa A. Parasnis, Ethan Ancell, Yulong Li, Larry S. Zweifel, Benjamin B. Land, Nephi Stella, Michael R. Bruchas 2026-08-26 doi:10.1038/s41586-026-10967-w

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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:27:21.873545 UTC

Endocannabinoids act as retrograde signals within a thalamostriatal circuit.
Their dynamic release regulates circuit gain during reward-seeking behavior.
This mechanism facilitates behavioral engagement with potential rewards.
The findings connect circuit-level neuromodulation to motivated behavior.

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