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Late-life semaglutide treatment slows ageing and extends lifespan in female mice

Research Medical/Healthcare AI

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TL;DR - A Nature study reports that three months of late-life semaglutide treatment improved physiological function, reduced ageing-associated hallmarks, and extended lifespan in female mice. The findings suggest potential geroprotective effects, but evidence provided is limited to a preclinical female-mouse study.

  • Treatment was administered late in life for three months.
  • Semaglutide attenuated multiple hallmarks of ageing.
  • The intervention modulated nutrient-sensing pathways and conserved genetic regulators of ageing.
  • Whether these effects generalize to male mice or humans is not established by the provided content.

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Late-life semaglutide treatment slows ageing and extends lifespan in female mice

Nature Yufan Feng, Marine Barthez, Yifei Wang, Yibing Chen, Huixian Qiu, Chih-Ling Wang, Kartoosh Heydari, Melaine Delcroix, Lene Juel Rasmussen, Vilhelm A. Bohr, Danica Chen 2026-09-02 doi:10.1038/s41586-026-10940-7
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:24:17.512595 UTC

TL;DR - A Nature study reports that three months of late-life semaglutide treatment improved physiological function, reduced ageing-associated hallmarks, and extended lifespan in female mice. The findings suggest potential geroprotective effects, but evidence provided is limited to a preclinical female-mouse study.

  • Treatment was administered late in life for three months.
  • Semaglutide attenuated multiple hallmarks of ageing.
  • The intervention modulated nutrient-sensing pathways and conserved genetic regulators of ageing.
  • Whether these effects generalize to male mice or humans is not established by the provided content.
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