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A retinoic acid autoregulatory loop governing prefrontal–motor arealization

Research Neurodevelopmental Biology

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TL;DR - This Nature study identifies MEIS2 as a central hub in a retinoic-acid-associated gene regulatory network governing prefrontal–motor cortical arealization. The finding may help connect early brain-region development with intellectual disability and autism spectrum disorder.

  • MEIS2 encodes a transcription factor associated with neurodevelopmental disorders.
  • The study describes a retinoic acid autoregulatory loop involved in cortical area specification.
  • The provided abstract snippet does not detail the experimental methods or specific mechanistic results.

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A retinoic acid autoregulatory loop governing prefrontal–motor arealization

Nature Lin Yang, Mikihito Shibata, Saejeong Park, Yuting Liu, Iva Salamon, Jia Liu, Suel-Kee Kim, Akemi Shibata, Ashley Deveau-French, Xoel Mato Blanco, Suxia Bai, Timothy Nottoli, Xiaojun Xing, Narjes Rohani, Stephan J. Sanders, Rothem Kovner, Kartik Pattabiraman, Nenad Sestan 2026-09-16 doi:10.1038/s41586-026-11014-4
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:17:48.163423 UTC

TL;DR - This Nature study identifies MEIS2 as a central hub in a retinoic-acid-associated gene regulatory network governing prefrontal–motor cortical arealization. The finding may help connect early brain-region development with intellectual disability and autism spectrum disorder.

  • MEIS2 encodes a transcription factor associated with neurodevelopmental disorders.
  • The study describes a retinoic acid autoregulatory loop involved in cortical area specification.
  • The provided abstract snippet does not detail the experimental methods or specific mechanistic results.
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