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The gene-regulatory evolution of the human skeleton

Research Bioinformatics AI

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TL;DR - This Nature study uses massively parallel reporter assays and human–ape hybrid skeletal cells to examine how human cis-regulatory elements evolved. It links regulatory DNA differences to changes in the cellular composition of human skeletal tissue.

  • Studies gene-regulatory evolution rather than changes in protein-coding genes.
  • Tests cis-regulatory element activity at scale with massively parallel reporter assays.
  • Uses human–ape hybrid skeletal cells to compare regulatory effects across species.
  • Provides evidence that CRE divergence helped shape distinctively human skeletal tissue composition.

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The gene-regulatory evolution of the human skeleton

Nature Yizhi Yan, Nadav Mishol, Katharina Lange, Zicong Zhang, Gal Bodek, Aya Kigel, Noam Priel, Nachshon Egyes, Omer Ronen, Itamar Nini, Liat Rotenstreich, Amit Philosoph, Sira Martinez, Silvia Beltramone, Rika Tsujikawa, Adi Rozenblatt, Lucas Esteban Wange, María Torralvo, Guy Hirsh, Yael Elboim, Sergey Viukov, Idan Korenfeld, Mythili Damal Kandadai, Océane Cluzeau, Malka Nissim-Rafinia, Eran Meshorer, Jacob H. Hanna, Evie Vereecke, Assaf Marom, Martin Kuhlwilm, Guillaume Bourque, Tomas Marques-Bonet, Simon Fishilevich, Fumitaka Inoue, David Gokhman 2026-09-23 doi:10.1038/s41586-026-11053-x
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Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:16:29.267606 UTC

TL;DR - This Nature study uses massively parallel reporter assays and human–ape hybrid skeletal cells to examine how human cis-regulatory elements evolved. It links regulatory DNA differences to changes in the cellular composition of human skeletal tissue.

  • Studies gene-regulatory evolution rather than changes in protein-coding genes.
  • Tests cis-regulatory element activity at scale with massively parallel reporter assays.
  • Uses human–ape hybrid skeletal cells to compare regulatory effects across species.
  • Provides evidence that CRE divergence helped shape distinctively human skeletal tissue composition.
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