🛰️ Daily AI Frontier
‹ back to 2026-09-24

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

Research Bioinformatics AI

Ranking

Overall 84
Content 90
Popularity 68

Observed public metrics from 1 member.

Merged summary

TL;DR - This Nature study presents a lifespan single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex. It reveals non-linear, cell-type-specific gene-expression changes across development, midlife, and late adulthood.

  • Transcriptional programs undergo dynamic remodelling during brain development.
  • Gene-expression patterns are comparatively stable in midlife.
  • Late adulthood selectively reactivates some molecular programs.
  • The atlas provides a cell-resolved framework for studying human cortical ageing.

Sources (1)

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

Nature Hui Yang, Tereza Clarence, Madeline R. Scott, Xinyi Wang, Prashant N. M., Milos Pjanic, Sanan Venkatesh, Aram Hong, Clara Casey, Sarah R. Murphy, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Alexander Kawah Yu, Athan Z. Li, Biao Zeng, Chenfeng He, Chirag Gupta, Christian Dillard, Christian Porras, Collin Spencer, Daifeng Wang, David A. Bennett, David Burstein, Deepika Mathur, Fotios Tsetsos, Gennadi Ryan, Jennifer Monteiro Fortes, Jerome J. Choi, Kalpana H. Arachchilage, Karen Therrien, Lars J. Jensen, Lisa L. Barnes, Logan C. Dumitrescu, Lyra Sheu, Marios Anyfantakis, Maxim Signaevsky, Mikaela Koutrouli, Monika Ahirwar, Nicolas Y. Masse, Noah Cohen Kalafut, Pavel Katsel, Pengfei Dong, Pramod B. Chandrashekar, Rachel Bercovitch, Roman Kosoy, Saniya Khullar, Sayali A. Alatkar, Seon Kinrot, Steven Finkbeiner, Steven P. Kleopoulos, Timothy J. Hohman, Ting Jin, Vivek G. Ramaswamy, Xiang Huang, Zhenyi Wu, Nadejda M. Tsankova, Pavan K. Auluck, Stefano Marenco, Vahram Haroutunian, Georgios Voloudakis, Jaroslav Bendl, Colleen A. McClung, Donghoon Lee, John F. Fullard, Gabriel E. Hoffman, Kiran Girdhar, Panos Roussos 2026-09-23 doi:10.1038/s41586-026-10271-7
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:16:22.353651 UTC

TL;DR - This Nature study presents a lifespan single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex. It reveals non-linear, cell-type-specific gene-expression changes across development, midlife, and late adulthood.

  • Transcriptional programs undergo dynamic remodelling during brain development.
  • Gene-expression patterns are comparatively stable in midlife.
  • Late adulthood selectively reactivates some molecular programs.
  • The atlas provides a cell-resolved framework for studying human cortical ageing.
item →