Cell：华人团队开发新型计算框架——「蒲公英」，发现哮喘核心致病基因，带来治疗新靶点

TL;DR - A Cell study introduces DANDELION, a computational framework that integrates trans-regulatory effects with exome burden data to prioritize disease-driving genes. Applied to asthma, it identified SLC27A3 and SCD and implicated protein palmitoylation in lung inflammation.

• DANDELION targets disease-proximal genes that mediate effects from more distal disease-associated genes.
• It identified candidates missed by GWAS and polygenic priority scoring methods such as PoPS.
• CRISPR screens showed that most prioritized genes regulate asthma-relevant epithelial and T-cell phenotypes.
• Mouse studies linked SLC27A3 and SCD to airway inflammation and remodeling, suggesting new therapeutic targets.